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目的探讨不同类的降压药物和不同钙拮抗剂对慢性脑血管病患者中血压变异性的影响。方法入选373例有慢性脑血管病的高血压患者,分别给予钙拮抗剂(CCBs)、(受体阻断剂(BBs)、血管紧张素转换酶抑制剂(ACEIs)和血管紧张素Ⅱ受体拮抗剂(ARBs)治疗后,行24h动态血压计算血压变异性,并进行统计分析。结果 BBs的日间血压变异性明显高于ARB或CCB(P<0.05),相比于其他CCB药物,西尼地平的日间血压变异性最低。结论 ARB和CCB相比于BBs更有利于脑血管疾病患者的高血压管理和治疗。而CCB中,由于较小的血压变异性,优选西尼地平。
Objective To investigate the effects of different classes of antihypertensive drugs and different calcium antagonists on blood pressure variability in patients with chronic cerebrovascular disease. Methods A total of 373 hypertensive patients with chronic cerebrovascular disease were enrolled in this study. The patients were given CCBs, BBs, ACEIs and angiotensin Ⅱ receptor (ARBs), blood pressure variability was measured 24h and then statistical analysis was performed.Results The daytime BPV of BBs was significantly higher than that of ARB or CCB (P <0.05). Compared with other CCB drugs, Daytime variability of nimdipine was lowest.Conclusion ARB and CCB are more favorable for the management and treatment of hypertension in patients with cerebrovascular disease than BBs, whereas in CCB, cilnidipine is preferred due to less variability in blood pressure.