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目的 检测hMLH1基因的蛋白表达 ,探讨其与卵巢上皮癌生物学行为的关系。方法 应用免疫组化SP法检测 46例卵巢上皮癌中hMLH1基因蛋白的表达。结果 46例卵巢上皮癌中 32例hMLH1蛋白表达阳性 ,占 6 9 6 %。病理学分级 1～ 2级hMLH1表达率明显高于 3级 (P <0 0 5 )。无淋巴结转移组hMLH1表达率高于有淋巴结转移组 (P <0 0 5 )。hMLH1的表达与组织学类型及临床分期无明显的相关性。结论 hMLH1基因可能在卵巢上皮癌的发生、发展过程中起一定的作用 ,且与卵巢上皮癌的恶性程度有关。对其检测将有助于判断卵巢上皮癌的恶性程度及估计预后。
Objective To detect the protein expression of hMLH1 gene and explore its relationship with the biological behavior of epithelial ovarian cancer. Methods The expression of hMLH1 gene in 46 cases of epithelial ovarian cancer was detected by immunohistochemical SP method. Results The positive expression of hMLH1 in 32 of 46 cases of ovarian epithelial carcinoma was 69.6%. Pathological grade 1 to 2 hMLH1 expression was significantly higher than the 3 (P <0 05). The expression of hMLH1 in non-lymph node metastasis group was higher than that in lymph node metastasis group (P <0.05). hMLH1 expression and histological type and clinical stage no significant correlation. Conclusion The hMLH1 gene may play an important role in the occurrence and development of epithelial ovarian cancer, and is related to the malignancy of epithelial ovarian cancer. The detection of ovarian cancer will help determine the degree of malignancy and prognosis.