肿瘤的生长和转移依赖于血管生成[1,2 ] 。肿瘤血管形成不仅为肿瘤提供丰富的营养和生长基质 ,而且为肿瘤的转移提供了重要的通道 ,因此 ,研究肿瘤血管形成的调控机制 ,对抑制肿瘤血管生成、抗肿瘤治疗具有重要的意义。肿瘤细胞可通过合成分泌血管生成因子调节肿瘤组织的血管生 Tumor growth and metastasis depend on angiogenesis [1,2]. Tumor angiogenesis not only provides rich nutrition and growth matrix for tumor, but also provides an important channel for tumor metastasis. Therefore, it is important to study tumor angiogenesis regulation mechanism to inhibit tumor angiogenesis and anti-tumor therapy. Tumor cells can regulate the angiogenesis of tumor tissue through the synthesis and secretion of angiogenic factors