目的　研究肺结核病人耐药原因 ,探讨耐药肺结核病防治对策。方法　对 5 6 6例痰菌培阳肺结核病人耐药性情况进行统计分析。结果　 5 6 6例痰菌培阳肺结核病例中 ,耐药患者 345例 ,占 6 0 .9% ;其中耐多药的有 2 5 0例 ,占总患者的 4 4 .2 % ,占耐药患者的 72 .5 %。导致病人耐多药的主要原因是不规则用药。结论　我省肺结核病人耐药情况严重。应加强病人管理 ,运用有效、合理的治疗方案治病。 Objective To study the causes of drug resistance in patients with pulmonary tuberculosis and to explore the strategies of prevention and treatment of drug-resistant pulmonary tuberculosis. Methods Statistical analysis was performed on the drug resistance of 566 sputum bacilli positive pulmonary tuberculosis patients. Results Among 566 sputum bacilli-positive pulmonary tuberculosis cases, 345 cases were drug-resistant, accounting for 60.9% of them; 250 cases were resistant to MDR, accounting for 44.2% of the total, accounting for drug-resistant 72.5% of patients. The main reason leading to MDR patients is irregular medication. Conclusions Our province has a serious resistance to pulmonary tuberculosis. Patients should be strengthened management, the use of effective and rational treatment programs for treatment.