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[目的]探讨调强放疗联合不同时间化疗对鼻咽癌患者腮腺功能的影响。[方法]初治鼻咽鳞癌患者39例,均无腮腺病史,随机分为单放组(单纯调强放射治疗)、放化组1(放疗第1周配合化疗)和放化组2(放疗第三周配合化疗)3组,每组13例。全组患者均采用全靶区调强放射治疗,化疗采用顺铂+多西紫杉醇。[结果]与单放组相比,放化组肿瘤局部控制率提高,但腮腺损伤加重,且放化组1对腮腺损伤更重。[结论]选择恰当时间放化治疗结合,可提高疗效,减少腮腺组织损伤。
[Objective] To investigate the effect of intensity modulated radiotherapy combined with chemotherapy on parotid gland function in patients with nasopharyngeal carcinoma. [Methods] 39 patients with newly diagnosed nasopharyngeal squamous cell carcinoma were randomly divided into radiotherapy group (radiotherapy alone), radiotherapy group 1 (radiotherapy combined with chemotherapy) and radiotherapy group 2 Radiotherapy with the third week of chemotherapy) 3 groups, 13 cases in each group. All patients were used to target the whole area IMRT chemotherapy with cisplatin + docetaxel. [Result] The local control rate of radiotherapy group was higher than that of radiotherapy group, but the parotid gland injury was aggravated, and parotid gland injury was more serious in radiotherapy group 1. [Conclusion] Choosing radiotherapy and radiotherapy at the right time can improve curative effect and reduce parotid gland tissue injury.