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乳腺癌的发生和发展与癌基因和抑癌基因的表达有密切相关,其中抑癌基因是抵御乳腺癌发生、发展的最重要的保护机制。ING1基因是ING基因家族中最先发现的抑癌基因。本文对ING1基因的结构、生物学功能及其与乳腺癌的关系做一综述。1ING1基因1996年Garkavtsev等〔1〕采用cDNA消减
The occurrence and development of breast cancer is closely related to the expression of oncogenes and tumor suppressor genes, of which the anti-oncogene is the most important protection mechanism against the occurrence and development of breast cancer. The ING1 gene is the first tumor suppressor gene found in the ING gene family. This review summarizes the structural, biological functions of ING1 and its relationship with breast cancer. 1ING1 gene 1996 Garkavtsev [1] cDNA subtraction