给7例进行性多发性骨髓瘤患者,以9mg/m~2/24h连续输注阿霉素(Adriamycin)96h(尚加用长春新碱,口服地塞米松),对其血浆和细胞(有核血细胞、骨髓细胞和增生性浆细胞)中的阿霉素浓度进行了测定。并与冲击注射法给药(每次30mg/m~2)时测得的浓度(以另9名患者实验)进行了对比。结果连续输注阿霉素的96h期间,输注开始后3h即能检测到血浆中阿霉素。输注48h后药浓度达稳定状态,72h和96h血浆浓度 Seven patients with progressive multiple myeloma were treated with continuous infusion of Adriamycin at 9 mg / m ~ 2 / 24h for 96 h (with vincristine plus oral dexamethasone) and their plasma and cells Nucleated cells, myeloid cells, and proliferative plasma cells). And compared with the concentration measured at the time of injection (30 mg / m ~ 2 at each time) (in another 9 patients). Results During the 96 h continuous infusion of doxorubicin, doxorubicin was detected in plasma at 3 h after the start of infusion. After 48h infusion drug concentration reached steady state, 72h and 96h plasma concentrations