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sesns是一类高度保守的应激诱导蛋白,可保护细胞免受氧化应激损害。然而,它们的生理及生化作用并不依赖其氧化还原活性。在哺乳动物和果蝇中,sesns可促进腺苷酸活化蛋白激酶(AMPK)的活化。应激可引起sesns表达,从而抑制雷帕霉素靶点复合物1。果蝇的sesns(dSesn)可以看作是雷帕霉素靶点的一种负反馈调节剂。近年来,sesns在应激、癌症、新陈代谢及衰老方面的作用受到越来越多的关注。
sesns is a highly conserved stress-inducible protein that protects cells from oxidative stress. However, their physiological and biochemical effects do not depend on their redox activity. In mammals and flies, sesns can promote the activation of adenylate activated protein kinase (AMPK). Stress can cause sesns expression, thereby inhibiting the target of rapamycin complex 1. Drosophila sesns (dSesn) can be seen as a negative feedback regulator of rapamycin targets. In recent years, the role of sesns in stress, cancer, metabolism and aging has received increasing attention.