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目的：测定肾小球细胞外基质（ＥＣＭ）中透明质酸（Ｈｙａｌｕｒｏｎｉｃ，ＨＡ）、层粘蛋白（Ｌａｍｉｎｉｎ，ＬＮ）的含量变化，以探讨其在肾小球硬化机制中的作用。方法：采用放射免疫法对３２例肾小球肾炎患者和１５例正常肾组织进行测定。结果：肾组织中ＨＡ、ＬＮ和前胶原－３（ＰＣ－３）随病变进展明显增加。结论：ＨＡ、ＬＮ和ＰＣ－３与肾小球硬化密切相关
Objective: To determine the content of hyaluronic acid (HA) and laminin (LN) in glomerular extracellular matrix (ECM) in order to explore its role in the mechanism of glomerulosclerosis. Methods: 32 cases of glomerulonephritis and 15 cases of normal renal tissue were determined by radioimmunoassay. Results: The levels of HA, LN and procollagen-3 (PC-3) in renal tissue were significantly increased with the progression of the disease. Conclusion: HA, LN and PC-3 are closely related to glomerulosclerosis