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目的:探讨原发性高血压患者微量白蛋白尿(MAU)与凝血纤溶指标的关系。方法:入选尿常规蛋白阴性的原发性高血压患者58例及健康对照者18例,分别进行临床和生化指标的检测。结果:根据尿微量白蛋白检测结果,高血压患者分为MAU组27例和NMAU(正常MAU)组31例,MAU组收缩压、舒张压、尿微量白蛋白及凝血纤溶指标中的纤维蛋白原、D-二聚体定量与对照组及NMAU组比较显著性增高(P<0.05)。多元相关分析显示,尿微量白蛋白水平与纤维蛋白原和D-二聚体定量均呈显著性正相关(r=0.613,P<0.01;r=0.842,P<0.01),纤维蛋白原与D-二聚体定量亦呈显著性相关(r=0.694,P<0.01)。结论:纤维蛋白原和D-二聚体定量与高血压患者尿微量白蛋白水平密切相关,提示高血压早期肾损伤时期即存在凝血纤溶指标变化,早期干预凝血纤溶系统的紊乱对减少心血管并发症有一定意义。
Objective: To investigate the relationship between microalbuminuria (MAU) and coagulation and fibrinolysis in patients with essential hypertension. Methods: Fifty-eight patients with urinary protein-negative primary hypertension and 18 healthy controls were enrolled in this study. The clinical and biochemical indexes were detected respectively. Results: According to the results of urinary microalbuminuria, the patients with hypertension were divided into MAU group (n = 27) and NMAU group (n = 31). The systolic blood pressure, diastolic blood pressure, urine microalbuminuria and coagulation and fibrinolysis index The original, D-dimer quantification and control group and NMAU group was significantly higher (P <0.05). Multivariate correlation analysis showed that urine microalbumin level was positively correlated with fibrinogen and D-dimer (r = 0.613, P <0.01; r = 0.842, P <0.01) - dimer also showed a significant correlation (r = 0.694, P <0.01). Conclusion: The quantitative analysis of fibrinogen and D-dimer is closely related to the level of urinary albumin in patients with hypertension. It suggests that coagulation and fibrinolysis changes in early stage of hypertension after hypertension. Intervention of early disturbance of coagulation and fibrinolysis system can decrease heart Vascular complications have some significance.