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抗生素的生物合成是由碳、氮源、磷酸盐和其它代谢物调节的.铵对抗生素(泰乐星和吉他霉素)生物合成的抑制效应已由几个作者描述,但是对于螺旋霉素生物合成直到现在发表的资料很少.铵离子通过干扰氨基酸如缬氨酸、苏氨酸、亮氨酸和异亮氨酸的分解代谢而减少泰乐星及螺旋霉素的生物合成.这些氨基酸供应泰乐星和螺旋霉素生物合成前体的低级脂肪酸、铵抑制用于糖苷配基形成的前体供应,但是不影响低级脂肪酸至糖苷配基的缩合.本实验室的研究显示:氨基酸与怎样消除氨功能和供给螺旋霉素前体如乙酸盐、丙酸盐和异丁酸盐的能力有关,它对螺旋霉素产生的影响是非常不同的.本文检验了铵在螺旋霉素产生上的作用、蛋白酶合成.铵效应的逆转.
The biosynthesis of antibiotics is regulated by carbon, nitrogen sources, phosphates and other metabolites.The inhibitory effect of ammonium on the biosynthesis of antibiotics (tylosin and guitarmycin) has been described by several authors, but for spiramycin organisms There is very little data available so far for the synthesis.Ammonium ions reduce the biosynthesis of telotaxin and spiramycin by interfering with the catabolism of amino acids such as valine, threonine, leucine and isoleucine These amino acid supplies The lower fatty acids of telbuterol and spiramycin biosynthesis precursors, ammonium, inhibit the supply of precursors for aglycone formation but do not affect the condensation of lower fatty acids to aglycones. Our laboratory studies show that amino acids and how Elimination of ammonia function is associated with the ability to supply spiramycin precursors such as acetate, propionate, and isobutyrate which have very different effects on spiramycin production.This article examined the effect of ammonium on spiramycin production The role of protease synthesis. The reversal of ammonium effect.