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目的 探讨谷氨酸对大鼠背部皮神经自发传入放电的影响。方法 采用体内分离脊神经背侧皮支单纤维记录方法,在皮神经感受野注射谷氨酸受体的激动剂谷氨酸钠(0. 3mmol/L, 10μl),观察对皮肤感觉神经传入放电的影响及时程变化。结果 将谷氨酸钠注射入Aδ和C类感受单位的感受野,注射过程中(7min)和注射后(10min)每分钟的平均传入放电数与注药前比较均显著增加(P<0. 05 )。但Aβ感受单位注射过程中和注射后平均传入放电数与给药前相比无显著性差异(P>0. 05)。同时还发现谷氨酸钠对Aδ和C类初级传入末梢的兴奋作用可见于所观察的整个时段。结论 谷氨酸可能参与外周痛敏化过程。
Objective To investigate the effect of glutamate on spontaneous discharge in the dorsal cutaneous nerve of rats. Methods In vivo separation of the dorsal branch of the dorsal branch of the spinal cord by a single fiber recording method, the glutamate receptor agonist glutamate (0. 3mmol / L, 10μl) was injected into the dermal nerve receptive field to observe the sensory nerve afferent discharge Influence and change of schedule. Results The average number of injections of sodium glutamate injected into the receptive fields of Aδ and C sensory units during injection (7 min) and injection (10 min) increased significantly compared with that before injection (P <0 . 05). However, there was no significant difference in the number of Aβ sensory unit injection and the average number of injections after injection (P> 0.05). The excitatory effect of sodium glutamate on Aδ and C primary afferent terminals was also found throughout the observed period. Conclusion Glutamate may be involved in peripheral pain sensitization.