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目的探讨环孢菌素A(CsA)联合丙酸睾酮治疗慢性再生障碍性贫血(CAA)的临床疗效及不良反应。方法60例CAA患者随机分为治疗组和对照组。对照组采用丙酸睾酮治疗,治疗组在对照组的基础上给予CsA治疗。治疗结束后评价临床疗效,检测两组外周血白细胞(WBC)、血红蛋白(Hb)、血小板(PLT)水平,观察不良反应。结果治疗组临床疗效总有效率为83.3%,显著高于对照组(46.7%),相比较差异有统计学意义(P<0.05);治疗后两组患者外周血WBC、Hb、PLT明显升高,与治疗前比较差异有统计学意义(P<0.05),且治疗组显著高于对照组(P<0.05);治疗组不良反应显著低于对照组(P<0.05)。结论CsA联合丙酸睾酮治疗CAA疗效显著,不良反应小,值得临床推广。
Objective To investigate the clinical efficacy and adverse reactions of cyclosporine A (CsA) combined with testosterone propionate in the treatment of chronic aplastic anemia (CAA). Methods Sixty patients with CAA were randomly divided into treatment group and control group. The control group was treated with testosterone propionate. The treatment group was given CsA on the basis of the control group. After treatment, the clinical efficacy was evaluated. The levels of peripheral blood leucocytes (WBC), hemoglobin (Hb) and platelet (PLT) in both groups were measured to observe the adverse reactions. Results The total effective rate of the treatment group was 83.3%, significantly higher than that of the control group (46.7%), the difference was statistically significant (P <0.05); after treatment, WBC, Hb and PLT were significantly increased (P <0.05), and the treatment group was significantly higher than the control group (P <0.05). The adverse reactions in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion CsA combined with testosterone propionate in the treatment of CAA significant effect, adverse reactions, worthy of clinical promotion.