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目的 :评价胃癌患者手术前、后NK及T细胞动态变化。方法 :采用单克隆抗体方法及MTT法检测了36例胃癌患者手术前、后T淋巴细胞亚群 (TC)及自然杀伤细胞 (NK)活性 ,并与 30例正常对照进行了比较。结果 :术前患者CD3(+)、CD4(+)、CD4(+) /CD8(+)比值、NK细胞活性显著降低 (P <0 0 1。CD8(+)细胞增高 (P <0 0 1)。术后 2 0天 ,患者细胞免疫功能逐渐恢复。与术前比较除CD4(+)外 ,其余均有显著性意义 (P <0 0 5 )。结论 :胃癌患者细胞免疫功能与肿瘤的消长有密切关系。TC亚群和NK细胞活性可作为判定疗效和预后的一个重要监测指标
Objective: To evaluate the dynamic changes of NK and T cells in gastric cancer patients before and after surgery. Methods: The activity of T lymphocyte subsets (TCs) and natural killer cells (NK) in 36 gastric cancer patients before and after surgery was detected by monoclonal antibody method and MTT assay, and compared with 30 normal controls. Results: Preoperative CD3 (+), CD4 (+), CD4 (+) / CD8 (+) ratio and NK cell activity were significantly decreased (P <0.01) ) .After 20 days, cellular immune function gradually recovered.Compared with preoperative CD4 (+), the rest had significant (P <0 05) .Conclusion: The cellular immune function in patients with gastric cancer and tumor Growth and decline are closely related.TC subsets and NK cell activity can be used as an indicator of efficacy and prognosis of an important monitoring indicators