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由炎症细胞所释放的血小板激化因子(PAF),在大鼠中能活化中性白细胞,释放第二信使并介导粘膜溃疡和缺血。本文旨在探讨PAF 在溃疡性结肠炎(UC)发病机制中的作用。材料和方法:结肠粘膜活检标本取自26例活动性UC 的炎症部位和22名正常人。患者组男15,女11,平均年龄44.2±3.4岁;正常对照组男10,女12,平均年龄41.8±4.4岁。UC 患者在行活检前至少2周停服一切药物。病变累及直肠和乙状结肠者16例,累及脾
Platelet-activating factor (PAF), released by inflammatory cells, activates neutrophils in rats, releases second messengers and mediates mucosal ulceration and ischemia. This article aims to investigate the role of PAF in the pathogenesis of ulcerative colitis (UC). MATERIALS AND METHODS: Colon mucosal biopsy specimens were obtained from 26 inflamed parts of the active UC and 22 normal individuals. The patient group male 15, female 11, the average age of 44.2 ± 3.4 years; the normal control group male 10, female 12, the average age of 41.8 ± 4.4 years. UC patients stop taking all medications at least 2 weeks prior to biopsy. Lesions involving the rectum and sigmoid colon in 16 cases, involving the spleen