论文部分内容阅读
目的:探讨注射用双黄连对兔体内茶碱药物动力学参数的影响。方法:取家兔8只,采用自身对照法。首先静注氨茶碱注射液10 mg·kg-1,6 d后静注注射用双黄连196 mg·kg-1,qd,联用4 d,于第4天同时给予氨茶碱10 mg·kg-1,用TDx测定茶碱血清浓度,计算机拟合房室模型并计算药动学参数。结果:氨茶碱的药-时曲线符合一室模型。合用注射用双黄连前后,茶碱半衰期、消除速率常数、消除率、曲线下面积及表观分布容积均无显著变化(P>0．05)。结论:注射用双黄连对家兔体内氨茶碱药动学参数影响甚少,两药合用可能是安全的。
Objective: To investigate the effect of Shuanghuanglian injection on the pharmacokinetic parameters of theophylline in rabbits. Methods: Eight rabbits were taken and used self-control method. First, the aminophylline injection was intravenously administered at 10 mg·kg-1, 6 days later, Shuanghuanglian was injected at 196 mg·kg-1, qd for 4 days, and aminophylline 10 mg was given on the 4th day. Kg-1, the serum concentration of theophylline was measured by TDx, the computer was fitted to the atrioventricular model and the pharmacokinetic parameters were calculated. Results: The drug-time curve of aminophylline met the one-compartment model. Before and after injection of Shuanghuanglian, theophylline half-life, elimination rate constant, elimination rate, area under the curve, and apparent volume of distribution did not change significantly (P>0.05). Conclusion: Shuanghuanglian injection has little effect on aminophylline pharmacokinetic parameters in rabbits, and the two drugs may be safe.