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目的探讨血清睾丸酮含量测定在老年男性贲门癌中的临床价值。方法应用放射免疫测定法检测６０岁以上老年男性正常人３０例，贲门癌术前患者６０例、术后患者１９例的血清睾丸酮含量，应用ｔ检验进行统计学分析，行贲门癌组与正常人组比较，术前术后比较，病变浸润深度、大小、淋巴结转移与否分别比较。结果老年男性贲门癌术前睾丸酮显著低于对照组（１７６８±６１７ｖｓ２６３２±７４２ｎｍｏｌ／Ｌ，Ｐ＜０００１），术后睾丸酮明显升高（２７０５±７５５ｎｍｏｌ／Ｌ，Ｐ＜００１），病变浸润至浆膜外组织者睾丸酮低于局限在肌层者（Ｐ＜００１），睾酮与病灶大小及淋巴结转移与否无关（Ｐ＞００５）。结论血清睾丸酮检测可作为老年男性贲门癌诊断、术前切除可能性估计、术后治疗效果评价的临床参考指标
Objective To investigate the clinical value of serum testosterone in elderly men with cardiac cancer. Methods Radioimmunoassay was used to detect the serum testosterone levels in 30 normal males older than 60 years old, 60 preoperative cardiac cancer patients, and 19 postoperative patients. Statistical analysis was performed using t-test to identify patients with cardiac cancer and normal controls. Group comparison, preoperative and postoperative comparisons, depth of invasion, size, and lymph node metastasis were compared. Results Preoperative testosterone was significantly lower in elderly males with cardiac cancer than in controls (1768±617vs2632±742nmol/L, P<0001). Postoperative testosterone was significantly elevated (2705±7). 55nmol/L, P<001), Infiltration of the lesions into the extraserosal tissue was significantly lower in testosterone than in the muscular layer (P<001). Testosterone did not correlate with lesion size or lymph node metastasis (P>0) 05). Conclusion Serum testosterone test can be used as a clinical reference index for the diagnosis, assessment of the possibility of preoperative resection, and evaluation of postoperative treatment of cardiac cancer in elderly men.