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目的 探讨p16基因和PCNA在子宫内膜癌发生发展中的作用。方法 采用免疫组化技术检测子宫内膜癌组织中 p16蛋白和PCNA的表达。结果 子宫内膜癌组织 p16蛋白表达阳性率低于正常内膜组织(P <0 0 5 ) ,而PCNA表达高于正常内膜组织 (P <0 0 1) ,p16蛋白表达与子宫内膜癌组织学分级、淋巴转移相关 (P <0 0 5 ,P <0 0 5 ) ,PCNA指数与子宫内膜癌的临床分期、组织学分级、淋巴转移相关。p16蛋白表达阴性者预后差。结论 p16基因和PCNA可能参与子宫内膜癌的发生发展 ,p16蛋白检测可做为子宫内膜癌的预后指标。
Objective To investigate the role of p16 gene and PCNA in the development of endometrial carcinoma. Methods Immunohistochemistry was used to detect the expression of p16 protein and PCNA in endometrial carcinoma. Results The positive rate of p16 protein expression in endometrial carcinoma was lower than that in normal endometrial tissue (P <0.05), while the expression of PCNA was higher than that in normal endometrial tissue (P <0.01). The positive rate of p16 protein in endometrial carcinoma Histological grade and lymph node metastasis (P <0.05, P <0.05). PCNA index was correlated with clinical stage, histological grade and lymphatic metastasis of endometrial carcinoma. Poor prognosis of p16 protein negative. Conclusion The p16 gene and PCNA may be involved in the development of endometrial carcinoma. The detection of p16 protein may be used as a prognostic indicator of endometrial cancer.