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目的探讨多西紫杉醇联合顺铂二线化疗治疗进展期晚期胃癌的疗效。方法将78例晚期胃癌患者随机分为两组,每组39例。两组患者均于一线化疗失败或疾病进展后应用二线化疗治疗。对照组单用多西紫杉醇,实验组加用顺铂治疗。比较两组治疗效果与不良反应。结果实验组疾病控制率高于对照组(74.4%比43.6%),差异有统计学意义(P<0.05)。结论晚期进展期胃癌患者应用多西紫杉醇联合顺铂二线治疗可获得较高的疾病控制率。
Objective To investigate the efficacy of docetaxel combined with cisplatin in the treatment of advanced advanced gastric cancer. Methods 78 patients with advanced gastric cancer were randomly divided into two groups, 39 cases in each group. Two groups of patients in the first-line chemotherapy failure or disease progression after the application of second-line chemotherapy. The control group was treated with docetaxel alone and the experimental group was treated with cisplatin. The therapeutic effects and adverse reactions of the two groups were compared. Results The rate of disease control in the experimental group was higher than that in the control group (74.4% vs 43.6%), the difference was statistically significant (P <0.05). Conclusions Second-line treatment with docetaxel plus cisplatin in advanced advanced gastric cancer patients achieves a higher rate of disease control.