目的　比较特利加压素和施他宁治疗肝硬化患者急性食管静脉曲张破裂出血的疗效和安全性。方法　特利加压素治疗组 41例 ,静推 2mg后 ,每 4h静推 1mg ;施他宁治疗组 43例 ,静注 2 5 0 μg后 ,每 1h 2 5 0 μg连续静滴。观察两种药物的止血率、再出血率、死亡率和副作用。结果　特利加压素组治疗有效率 ( 80 5 % )类似于施他宁组 ( 83 7% ) ;两组再出血率分别为 19 5 %和 2 3 3 % (P >0 .0 5 ) ,死亡率分别为 12 2 %和 16 3 % (P >0 .0 5 )。特利加压素组副作用发生率为 7 3 % ,施他宁组无明显副作用。结论　特利加压素和施他宁均是治疗急性食管静脉曲张破裂出血的一线有效药物 Objective To compare the efficacy and safety of terlipressin and thantadine in the treatment of acute esophageal variceal bleeding in patients with liver cirrhosis. Methods 41 cases of terlipressin treatment group, 2mg intravenously, every 4h bolus 1mg; Stratanin treatment group 43 cases, intravenous injection of 250μg, every 1h continuous intravenous drip. Hemostatic rate, rebleeding rate, mortality and side effects of the two drugs were observed. Results The effective rate of treatment with terlipressin (80 5%) was similar to that of the group with shitamycin (83 7%); the rates of rebleeding were 19 5% and 23 3% (P 0.05) , The mortality rates were 122% and 163% respectively (P> 0.05). The incidence of side effects in the terlipressin group was 73%, and no significant side effects were observed in the sirtuin group. Conclusions Both terlipressin and sitatin are effective first-line agents for the treatment of acute esophageal variceal bleeding