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1例60岁女性患者因肝功能轻度异常口服硫普罗宁0.2 g,3次/d。约20 d后患者在服用硫普罗宁后十几分钟突然出现畏寒、发热,最高体温39.3℃。当地医院给予头孢呋辛、阿奇霉素、莫西沙星等药物治疗,但未停用硫普罗宁,患者症状无改善,且出现干咳、活动后气喘、肺水肿及胸腔积液,遂入我院。入院后仍给予抗感染治疗,但患者自行停用硫普罗宁,第2天患者体温即降至正常,4 d后患者各种症状好转出院。出院后2 d患者自行服用硫普罗宁0.2 g后十几分钟再次出现高热、畏寒,停药并给予退热处理,症状消失。
A 60-year-old female patient received oral oral administration of tiopronin 0.2 g 3 times daily for mild liver dysfunction. About 20 days after taking tiopronin patients ten minutes suddenly chills, fever, the maximum body temperature 39.3 ℃. Local hospital cefuroxime, azithromycin, moxifloxacin and other drug treatment, but did not disable tiopronin, the patient did not improve symptoms, and dry cough, wheezing, pulmonary edema and pleural effusion, and then into our hospital. Anti-infective treatment was still given after admission, but patients discontinued tiopronin on their own and their body temperature dropped to normal on the second day. After 4 days, the patients were relieved of various symptoms and discharged. Two days after discharge, patients taking pyrolanin 0.2 g ten times more appeared fever, chills, withdrawal after treatment and given antipyretic treatment, the symptoms disappeared.