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目的:探讨宁夏回族自治区出生缺陷发生的危险因素,为政府制定出生缺陷干预措施和对策提供依据。方法:设计统一的调查表,由经过培训的调查员对宁夏回族自治区的5个行政市22个市县(区)在2007年1月1日~12月31日出生的所有婴儿进行入户调查,资料进行单因素和多因素非条件Logistic回归分析。结果:出生缺陷发生率为128.72万/;多因素分析结果显示,孕早期发烧(OR=1.116)、孕早期服用抗生素(OR=1.559)、孕妇异常生育史(OR=1.281)、近亲结婚(OR=17.328)、早产(OR=1.147)、汉族(OR=1.471)、常住地为农村(OR=1.311)是出生缺陷的危险因素。结论:宁夏回族自治区出生缺陷干预应从加强婚前健康教育、避免近亲结婚、提倡婚前检查、做好孕早期防护和加强产前检查等方面入手。
Objective: To explore the risk factors of birth defects in Ningxia Hui Autonomous Region, and to provide evidence for the government to make interventions and countermeasures for birth defects. Methods: A unified questionnaire was designed, and all the infants born in 22 cities and counties (districts) of 5 administrative cities of Ningxia Hui Autonomous Region from January 1 to December 31, 2007 were investigated by trained investigators. Data were univariate and multivariate non-conditional logistic regression analysis. Results: The incidence of birth defects was 1287200 / multivariate analysis showed that the first trimester of pregnancy (OR = 1.116), the first trimester of antibiotics (OR = 1.559), the abnormal birth history of pregnant women (OR = 1.281) = 17.328), premature birth (OR = 1.147), Han (OR = 1.471), and rural areas (OR = 1.311) were risk factors for birth defects. Conclusion: The intervention of birth defects in Ningxia Hui Autonomous Region should start with strengthening premarital health education, avoiding marriage of relatives, premarital examination, early pregnancy protection and strengthening antenatal examination.