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对咪唑并吡啶类化合物作为环核苷酸磷酸二酯酶（PDE）的抑制剂的抑制活性进行了比较分子力场分析．结果表明，立体效应和静电作用场是描述对PDE仰制活性和进行结构性能关系研究的最重要的结构参数，提出了对该类化合物进行结构修饰的方法，并由新建立的三维定量构效关系模型对该类化合物的PDE抑制活性进行了预报．
Comparative molecular field analysis was performed on the inhibitory activity of imidazopyridine compounds as inhibitors of cyclic nucleotide phosphodiesterase (PDE). The results show that the stereoscopic effect and the electrostatic field are the most important structural parameters to describe the relationship between the activity and the structural properties of PDE. A new method for the structural modification of these compounds is proposed. The new three- The relationship model predicts the PDE inhibitory activity of these compounds.