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目的探讨血液灌流联合连续性肾脏替代治疗对急性重度有机磷农药中毒患者IL-4、TNF-α、IL-1β等炎症因子的影响。方法将我院收治的符合急性重度有机磷农药中毒诊断标准的住院患者分为治疗组和对照组,检测并比较两组治疗前及治疗后血清中IL-4、TNF-α、IL-1β水平。结果治疗后12 h,治疗组IL-4水平较对照组降低(P<0.05),TNF-α、IL-1β水平亦较对照组降低(均P<0.01);治疗后24 h,治疗组TNF-α、IL-1β水平较对照组降低(均P<0.05)。结论血液灌流联合连续性肾脏替代治疗通过对炎症因子的清除作用,为临床综合救治AOPP提供了新的方法。
Objective To investigate the effects of hemoperfusion combined with continuous renal replacement therapy on inflammatory factors such as IL-4, TNF-α and IL-1β in patients with acute severe organophosphorus pesticide poisoning. Methods The hospitalized patients who met the diagnostic criteria of acute severe organophosphorus pesticide poisoning in our hospital were divided into treatment group and control group. The levels of IL-4, TNF-α, IL-1β in serum before and after treatment were detected and compared . Results At 12 h after treatment, the level of IL-4 in the treatment group was lower than that in the control group (P <0.05), and the levels of TNF-α and IL-1 β in the treatment group were also lower than those in the control group -α, IL-1β levels were lower than the control group (all P <0.05). Conclusion Hemoperfusion combined with continuous renal replacement therapy through the clearance of inflammatory cytokines provides a new method for clinical treatment of AOPP.