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孕妇患疟疾可引起早产、IUGR、围产儿死亡及孕妇贫血和死亡,孕妇对疟疾特别易感,其易感性随妊娠进展而降低。胎盘是恶性疟原虫感染的红细胞(IRBC)容易隐藏的部位,外周循环中完全找不到疟原虫时胎盘上的疟原虫密度仍可很高。最近发现硫酸软骨素A(CSA)是IRBC的一种受体。 从被感染者胎盘获取IRBC,测定其与各种固定的细胞外基质蛋白的粘附,将小牛血清蛋白(BSA)作对照,发现与CSA结合的IRBC的数目是与BSA结合的22倍,而与其它胞外基质蛋白,包括硫酸软
Pregnant women suffering from malaria can cause premature birth, IUGR, perinatal mortality and anemia and death of pregnant women, pregnant women are particularly susceptible to malaria, its susceptibility decreases with the progress of pregnancy. The placenta is an easily concealed site of Plasmodium falciparum-infected red blood cells (IRBCs), and the placental parasites on the placenta remain highly densified when the parasite is completely missed in the peripheral circulation. Chondroitin Sulfate A (CSA) has recently been found to be a receptor of IRBC. IRBC was obtained from placenta of infected persons and its adhesion to various fixed extracellular matrix proteins was determined. Using bovine serum albumin (BSA) as a control, it was found that the number of IRBC bound to CSA was 22 times that of BSA, And with other extracellular matrix proteins, including sulfuric acid