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肝毒性是与应用抗逆转录病毒药物(ART)相关的不良反应,在治疗HIV感染时可增加患者的发病率和病死率,影响HIV感染的治疗。可能的机制包括直接的药物毒性、丙型肝炎病毒和(或)乙型肝炎病毒同时感染中的免疫重建、与肝相关的过敏性反应和线粒体毒性,还可能涉及其他致病途径。高活性抗逆转录病毒药物治疗(HAART)与转氨酶水平的升高相关。在HAART中每个单独的药物在肝毒性的发展中所起的作用难以确定。仍不清楚大多数ART肝毒性的发病率。
Hepatotoxicity is an adverse reaction associated with the use of antiretroviral drugs (ART), which may increase the morbidity and mortality of patients in the treatment of HIV infection and affect the treatment of HIV infection. Possible mechanisms include direct drug toxicity, immune reconstitution of hepatitis C virus and / or simultaneous infection with Hepatitis B, liver-related allergic reactions and mitochondrial toxicity, and may also involve other pathogenic pathways. Highly active antiretroviral therapy (HAART) is associated with elevated transaminases. The role of each individual drug in the development of hepatotoxicity in HAART is difficult to determine. The incidence of most ART hepatotoxicity remains unclear.