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目的分析初治鼻咽癌患者行调强适形放射治疗(IMRT)的疗效及预后因素。方法观察85例初治鼻咽癌患者IMRT治疗后的生存情况及不良反应。结果 3年总生存率为94.9%,局部控制率为92.4%,无远处转移生存率为92.4%,无区域淋巴结转移生存率为96.2%;急性不良反应大多为Ⅱ度急性口腔黏膜炎,Ⅰ～Ⅱ度急性皮肤反应,远期口干症多为Ⅰ～Ⅱ度,Ⅲ度口干症未见;单因素分析肿瘤T分期与患者总生存率无相关性,肿瘤N分期及临床分期与患者总生存率有关,放化疗综合治疗与单纯放疗与患者总生存率也无明显相关性。结论调强放疗对初治鼻咽癌患者疗效较好,且重度不良反应少见。
Objective To analyze the curative effect and prognostic factors of IMRT in newly diagnosed nasopharyngeal carcinoma patients. Methods The survival and adverse reactions of 85 nasopharyngeal carcinoma patients after IMRT treatment were observed. Results The overall 3-year survival rate was 94.9%, the local control rate was 92.4%, the distant metastasis-free survival rate was 92.4%, and the non-regional lymph node metastasis survival rate was 96.2%. Most of the acute adverse reactions were grade Ⅱ acute oral mucositis, Ⅰ ~ Ⅱ degree of acute skin reaction, long-term dry mouth mostly â ... ¡~ â ... ¡degree, â ... ¢ degree of dry mouth was not seen; univariate analysis of tumor T stage and the overall survival rate was not correlated, the tumor stage and clinical stage of patients with TNM The overall survival rate, radiotherapy and chemotherapy combined with radiotherapy alone and the overall survival rate was not significantly correlated. Conclusion IMRT has a good curative effect on patients with nasopharyngeal carcinoma, and severe adverse reactions are rare.