论文部分内容阅读
目的 探讨左旋精氨酸 (L- Arg)对高原肺水肿 (HAPE)治疗前后一氧化氮合酶 (NOS)的影响。 方法 在海拔 370 0 m采用静脉滴注 L- Arg治疗 HAPE患者 8例 ,并与吸入低浓度一氧化氮 (NO)混合气治疗的 8例 HAPE患者作对照 ,分别检测血中 NO及 NOS含量。 结果 吸入 NO组和 L- Arg组治愈后较治疗前 NO、NOS均增高显著 (P<0 .0 5或 P<0 .0 1) ;吸入 NO组较 L- Arg组治疗后 NO及 NOS均无统计学差异 (P>0 .0 5 )。 结论 吸入 NO和静滴 L- Arg均可提高 HAPE患者 NOS活性 ,但 L- Arg更经济简便 ,易于推广应用。
Objective To investigate the effect of L-arginine (L-Arg) on nitric oxide synthase (NOS) before and after treatment of high altitude pulmonary edema (HAPE). Methods 8 cases of HAPE were treated with intravenous infusion of L-Arg at an altitude of 370 m and compared with 8 HAPE patients treated with inhaled low concentration of nitric oxide (NO). The contents of NO and NOS in blood were detected respectively. Results NO and NOS in both inhaled NO and L-Arg groups were significantly higher than before treatment (P <0.05 or P <0.01), NO and NOS in inhaled NO group were significantly higher than those in L-Arg treated group No significant difference (P> 0.05). Conclusion Both inhaled NO and intravenous drip L-Arg can increase the activity of NOS in patients with HAPE. However, L-Arg is more economical and simple, and is easy to popularize and apply.