由于新喹诺酮制剂具有广泛的抗菌谱、极强的抗菌力和在组织内的快速扩散性能,因而该制剂得以在口服抗菌素中居主导地位。为了恰当使用此制剂,有必要了解其特点、存在的问题以及将来可能用于临床的某种新衍生物。新喹诺酮制剂的特点及存在的问题新喹诺酮制剂有适当的亲脂性、广抗菌谱、强抗菌力和高度的组织内扩散性能。体外试验可直接反映该制剂在体内的抗菌能力及临床效果。而抗菌能力有所提高是由于该制剂在组织内快速扩散的缘故。虽然该制剂的吸收不 Due to its broad spectrum of antibacterial properties, strong antibacterial activity and rapid diffusion within the tissue, the new quinolone formulation is therefore dominating oral antibiotics. In order to properly use this preparation, it is necessary to understand its characteristics, problems and some new derivatives that may be used clinically in the future. The characteristics of the new quinolone formulations and existing problems New quinolone formulations have appropriate lipophilicity, broad antibacterial spectrum, strong antibacterial and high intra-tissue diffusivities. In vitro tests can directly reflect the antibacterial ability and clinical effect of the preparation in the body. The increased antibacterial capacity is due to the rapid diffusion of the formulation within the tissue. Although the absorption of the preparation is not