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心房纤颤患者实施电复律后,多普勒超声测定的二尖瓣口流速曲线上A峰常减低,提示电复律后心房肌收缩功能下降,即存在“心房晕厥”现象。索他洛尔是第三代β-肾上腺素能受体阻滞剂,与同类其他药物相比,它对心室功能正常者的负性肌力作用较弱。对心室功能受损者的负性肌力作用较强,但对心房肌的作用尚不明确。本研究采用随机、安慰剂对照设计,了解索他洛尔对心房纤颤者电复律后心房功能的影响。
Atrial fibrillation in patients with cardioversion, Doppler ultrasound measured mitral flow velocity curve A peak often decreased, suggesting that electrical cardiomyocyte atrial systolic dysfunction, that there is “atrial syncope” phenomenon. Sotalol is a third-generation beta-adrenergic receptor blocker that has a negative inotropic effect on normal ventricular function compared to other drugs of the same class. Negative cardiac muscle function of impaired ventricular function, but the role of atrial muscle is not yet clear. This study randomized, placebo-controlled design to understand the impact of sotalol on atrial fibrillation electrical cardioversion atrial function.