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目的 :评价血清烯醇化酶及其 β-同工酶在急性心肌梗死 (AMI)诊断中的意义。方法 :对58例 AMI、38例非 AMI的心脏病、13例肌肉损伤的患者及 51例正常健康人应用免疫抑制法测定血清烯醇化酶β-同工酶活力。结果 :AMI患者血清烯醇化酶总活力及其β-同工酶活力均明显高于非 AMI患者和正常人。其敏感性分别为 93.0 %和 10 0 % ,特异性为 89.6 %和 92 .3%。结论 :血清烯醇化酶及其 β-同工酶具有升高时间早和持续时间长的特点 ,有助于 AMI的早期诊断 ,按时间序列动态观察有助于了解 AMI的病程演变
Objective: To evaluate the significance of serum enolase and its β-isoenzyme in the diagnosis of acute myocardial infarction (AMI). Methods: Serum enolase β-isoenzyme activity was measured by immunosuppression in 58 AMI patients, 38 non-AMI heart disease patients, 13 muscle injury patients and 51 healthy controls. Results: The serum total enolase activity and β-isozyme activity in AMI patients were significantly higher than those in non-AMI patients and normal controls. The sensitivity was 93.0% and 100% respectively, and the specificity was 89.6% and 92.3%. CONCLUSIONS: Serum enolase and its β-isoenzymes have the characteristics of early rise and long duration, which are helpful for the early diagnosis of AMI. Time-series dynamic observation helps to understand the course of AMI