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目的: 观察妊娠早期补充低剂量铁剂在预防妊娠期贫血中的疗效, 并观察治疗过程中的副反应。方法: 筛选早孕期符合研究条件的研究对象, 随机分为治疗组与对照组, 治疗组给予小剂量铁剂 8周后, 比较治疗组与对照组血红蛋白、血清铁蛋白、血清铁、总铁结合力、转铁蛋白饱和度的变化情况。结果: 治疗 8周后, 治疗组的血清铁蛋白、血清铁、转铁蛋白饱和度皆高于对照组, 其中血清铁与转铁蛋白饱和度有显著增加, 无明显的副作用发生。结论: 孕早期补充小剂量铁剂可有效增加血清铁水平, 有利于预防妊娠期贫血的发生, 且副反应少, 依从性较好。
OBJECTIVE: To observe the efficacy of low-dose iron supplementation in the prevention of anemia during pregnancy in early pregnancy and to observe the side effects in the course of treatment. Methods: The subjects in the first trimester who were eligible for the study were screened and randomly divided into treatment group and control group. The patients in the treatment group were treated with low dose iron for 8 weeks. The levels of hemoglobin, serum ferritin, serum iron and total iron in the treatment group and the control group were compared Force, transferrin saturation changes. Results: After 8 weeks of treatment, serum ferritin, serum iron and transferrin saturation of the treatment group were higher than those of the control group. Serum iron and transferrin saturation were significantly increased, with no obvious side effects. CONCLUSION: Supplementing small dose of iron in early pregnancy can effectively increase serum iron level, which is propitious to prevent the occurrence of anemia during pregnancy, with less side effects and better compliance.