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[目的]分析ICU患者临床诊断侵袭性肺曲霉菌病(Invasive Pulmonary Aspergillosis,IPA)的临床特点。[方法]对我院ICU2007年3月～2008年3月临床诊断IPA患者的临床特点进行回顾性分析。[结果]共13例IPA患者入选,其中8例既往有慢性阻塞性肺疾病(COPD)史,仅3例存在免疫抑制性疾病。IPA主要临床症状为进行性加重的呼吸困难,早期胸部影像学缺乏特异性,主要表现为炎性渗出和实变。即使给予积极治疗,IPA的预后很差。[结论]ICU患者IPA临床特点缺乏特异性,预后不良,应早期、足量、足疗程给予抗曲菌治疗。
[Objective] To analyze the clinical features of clinically diagnosed invasive pulmonary aspergillosis (IPA) in patients with ICU. [Methods] The clinical features of IPA patients diagnosed in our hospital from March 2007 to March 2008 were retrospectively analyzed. [Results] A total of 13 cases of IPA were enrolled. Among them, 8 had history of chronic obstructive pulmonary disease (COPD) and only 3 had immunosuppressive disease. IPA main clinical symptoms of progressive aggravating dyspnea, lack of specificity of early chest imaging, mainly for inflammatory exudate and consolidation. Even with aggressive treatment, IPA has a poor prognosis. [Conclusion] The clinical features of IPA in ICU patients are lack of specificity and the prognosis is poor. Anti-Aspergillus therapy should be given in early stage, adequate amount and full course.