目的探讨福建省妊娠期梅毒发病率及其对围产儿的影响。方法对2004年7月1日至2006年6月30日纳入调查对象,均在知情同意下进行快速血浆反应素(RPR)筛查,凡RPR阳性者进一步检测RPR滴度,同时行梅毒螺旋体血凝试验(TPHA)以确诊。对确诊为妊娠期梅毒孕妇进行跟踪调查直至分娩。并对每个确诊为妊娠期梅毒的孕妇进行产前问卷调查,对其所生新生儿填一份随访表。结果共有调查对象49575例,其中接受RPR筛查孕产妇45529例,查出RPR阳性并经TPHA确诊的妊娠期梅毒847例,其中已分娩772例,妊娠期梅毒发病率为1.70%(772/45529);绝大多数为潜伏梅毒;其围产儿死亡率为59.74‰、低体重发生率8.05%、早产率7.40%,均明显高于同期分娩非妊娠期梅毒之围产儿以上各率,P<0.01差异有统计学意义;围产儿预后与孕母RPR滴度有关,孕母RPR滴度<1∶8与滴度≥1∶8的比较,滴度高对围产儿的影响大,预后差,围产儿死亡率、早产率、低出生体重发生率高,P值均<0.01,差异有统计学意义。结论福建省妊娠期梅毒发病率逐年升高,绝大多数为潜伏梅毒;其围产儿死亡率、早产率、出生低体重发生率均高于非妊娠期梅毒之围产儿的以上各率;围产儿预后与孕母RPR滴度有关。 Objective To investigate the incidence of gestational syphilis in Fujian Province and its impact on perinatal children. Methods All subjects were enrolled in the study from July 1, 2004 to June 30, 2006. All patients underwent RPR screening with informed consent. All patients with RPR positive were further tested for RPR titer, while patients with Treponema pallidum Condensation test (TPHA) to confirm. Pregnant women diagnosed with gestational diabetes were followed up until childbirth. Prenatal questionnaires were also performed on each pregnant woman diagnosed with gestational syphilis, and a follow-up form was made for newborns born to them. Results A total of 49575 subjects were investigated. Among 45529 pregnant women receiving RPR screening, 847 cases of gestational syphilis were detected positive for RPR and diagnosed by TPHA, of which 772 had been delivered and the incidence of syphilis during pregnancy was 1.70% (772/45529 ); The vast majority of latent syphilis; its perinatal mortality rate was 59.74 ‰, the rate of low weight was 8.05% and the rate of premature delivery was 7.40%, which were significantly higher than those of perinatal non-pregnant syphilis during the same period of delivery (P <0.01) The difference was statistically significant; the prognosis of perinatal and pregnant mothers RPR titers, pregnant mothers RPR titer <1: 8 and titers ≥ 1: 8, the high titer of perinatal impact, poor prognosis, Wai Infant mortality rate, premature birth rate, low birth weight were high, P <0.01, the difference was statistically significant. Conclusions The incidence of syphilis in pregnancy is increasing year by year in Fujian Province, with the vast majority of latent syphilis. The rates of perinatal mortality, premature birth rate and low birth weight are higher than those of non-pregnant syphilis. Perinatal Prognosis and pregnant mothers RPR titer.