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10号染色体张力蛋白同源物磷酸脂酶(phosphataseandtensinhomologdeletedonchromosometen,PTEN)是迄今为止发现的第一个具有磷酸酯酶活性的抑癌基因,可能有抑制细胞与细胞外基质相互作用的功能[1]。目前研究提示在人类多种肿瘤和遗传性肿瘤易感综合征等疾病中常出现PTEN杂合性?
The phosphatase and tensinhomologdeleted on chromosome 10 (PTEN) is the first tumor suppressor gene with phosphatase activity found so far, and may have the function of inhibiting the interaction between cells and extracellular matrix [1]. The present study suggests that PTEN heterozygosity often occurs in many human tumors and hereditary tumors susceptible syndromes.