论文部分内容阅读
目的:探讨学龄期儿童认知功能事件相关电位(event-related potentials，ERPs)P300的发展特征。方法:180例7~12岁学龄期儿童按年龄分为7~8岁组(n n＝48)、9~10岁组(n n＝44)和11~12岁组(n n＝48)，并进行Oddball任务检测，采用SPSS 21.0软件对行为学结果及P300的亚成分P3a、P3b波幅、潜伏期进行分析。n 结果:(1)7~8岁组、9~10岁组、11~12岁组儿童击中数[49(47.25，50)个，50(49，50)个，50(50，50)个]、正确反应时[(533.37±56.94) ms，(486.91±61.12)ms，(411.55±51.97) ms]、虚报数[2(1，4)个，2(1，3)个，1(0，2)个]差异均有统计学意义(n F值/χn 2＝20.635，54.477，13.169，均n P<0.01)。(2)P3a波幅的年龄主效应(n F＝3.884，n P＝0.023)、年龄×刺激类型交互效应(n F＝3.314，n P＝0.038)显著，刺激类型主效应不显著(n F＝0.111，n P＝0.740)。11~12岁组靶P3a波幅[(11.02±6.00)μV]较7~8岁组[(7.36±4.48)μV]与9~10岁组[(7.76±5.17)μV]增高，差异有统计学意义(均n P0.05)。n 结论:P3a可能是学龄期儿童认知功能的敏感监测指标，11~12岁是儿童注意定向、选择能力发展的关键时期，可能与脑网络发育程度有关。“,”Objective:To investigate the characteristics of event-related potentials(ERPs)P300 in the development of attention cognitive function of school-age children.Methods:A total of 180 school-age children were divided into 3 groups according to their ages (7-8 years old group with 48 cases, 9-10 years old group with 44 cases and 11-12 years old group with 48 cases). All of the participants completed an Oddball task, and their behavioral data, P3a and P3b components of ERPs were analyzed by SPSS 21.0.Results:(1)The differences of hit numbers(49(47.25, 50), 50(49, 50), 50(50, 50) ), correct reaction time((533.37±56.94) ms, (486.91±61.12) ms, (411.55±51.97) ms), and Omission errors (2(1, 4), 2(1, 3), 1(0, 2) ) among the three groups were statistically significant(n F/χn 2=20.635, 54.477, 13.169, all n P<0.01). (2)There was a main effect of age(n F=3.884, n P=0.023) and an interaction effect between age and condition(n F=3.314, n P=0.038) on the amplitude of P3a, while the main effect of condition was not significant(n F=0.111, n P=0.740). The amplitude of P3a component in 11-12 years old group ((11.02±6.00)μV) was significantly larger than that of 7-8 years old group ((7.36±4.48)μV) and 9-10 years old group ((7.76±5.17)μV, bothn P0.05).n Conclusion:P3a may be a sensitive indicator of cognitive function in school-age children, and the age of 11-12 years old is a sensitive period for the development of children's attention orientation and selection ability, which may be related to the development of brain network.