We previously show that fatty acid-binding protein 3(FABP3)triggers α-synuclein(Syn)accumulation and induces dopamine neuronal cell death in Parkinson disease mouse model.But the role of fatty acid-binding protein 7(FABP7)in the brain remains unclear.In t
Hepatic stellate cells(HSCs)play an important role in the initiation and development of liver fibrogenesis,and abnormal glucose metabolism is increasingly being considered a crucial factor controlling phenotypic transformation in HSCs.However,the role of
We previously showed that oral administration of exogenous glutathione(GSH)exerted a direct and/or indirect therapeutic effect on ischemic stroke rats,but the underlying mechanisms remain elusive.In the current study,we conducted a quantitative proteomic
Major depression disorder is a severe and recurrent neuropsychological disorder characterized by lowered mood and social activity and cognitive impairment.Owing to unclear molecular mechanisms of depression,limited interventions are available in clinic.In
Cardiac hypertrophy is a common adaptive response to a variety of stimuli,but prolonged hypertrophy leads to heart failure.Hence,discovery of agents treating cardiac hypertrophy is urgently needed.In the present study,we investigated the effects of QF8413
Alzheimer\'s disease(AD)is associated with high incidence of cardiovascular events but the mechanism remains elusive.Our previous study reveals a tight correlation between cardiac dysfunction and low mitochondrial aldehyde dehydrogenase(ALDH2)activity i
Interleukin-17A(IL-17),a potent proinflammatory cytokine,has been shown to participate in cardiac electrical disorders.Diabetes mellitus is an independent risk factor for ventricular arrhythmia.In this study,we investigated the role of IL-17 in ventricula
Harmine is a β-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological activities,including antioxidant,anti-inflammatory,antitumor,anti-depressant,and anti-leishmanial capabilities.Nevertheless,the pharmacolog
Cardiac fibrosis(CF)is an irreversible pathological process that occurs in almost all kinds of cardiovascular diseases.Phosphorylation-dependent activation of c-Jun N-terminal kinase(JNK)induces cardiac fibrosis.However,whether S-nitrosylation of JNK medi
众创空间是围绕促进“大众创业、万众创新”的新型创业服务载体.为贯彻落实《国务院办公厅关于发展众创空间推进大众创新创业的指导意见》,积极推进云南省大众创业、万众创新工作,2015年以来,云南省先后出台了《关于发展众创空间推进大众创新创业的实施意见》《关于加快众创空间发展服务实体经济转型升级实施意见》《云南省众创空间认定管理办法》等政策文件,明确了云南省众创空间建设的指导思想、发展目标、主要任务和组织实施等.云南省科学技术厅先后组织了 6批众创空间的培育认定,实现16个州(市)全面覆盖,全省形成了国家、省、州