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[目的]探讨血清直接胆红素(DBIL)和碱性磷酸酶(ALP)增高患者全麻中接受羟考酮与右美托咪定(Dex)联用后对麻醉相关指标变的影响.[方法]梗阻性黄疸或肝细胞黄疸致DBIL和ALP增高患者60例,随机分为对照组(M组)和羟考酮联合Dex组(观察组,Q组),M组给予静吸复合全麻,Q组在麻醉诱导前10min静脉注射羟考酮4mg,泵注Dex0.5μg/(kg·h)至缝皮前25min结束.比较两组麻醉相关情况.[结果]两组拔管时间比较差异无显著性(P>0.05),Q组丙泊酚总量、瑞芬太尼总量少于M组(P0.05),and the total amount of propofol and remifentanil in the group Q was less than that in the group M (P <0.05);In the group Q,1min(T1)after intubation,1min(T2)after extubation,heart rate(HR)and mean arterial pressure(MAP)at 10min(T3)after extubation were lower than those in the group M,and the difference was significant(P <0.05);In the group Q,the visual analogue scale(VAS)at extubation and 10min after extu-bation was lower than that in the group M,and the Ramsy score was higher in group than that in the group M(P0.05).[Conclusion]The application of oxycodone hydrochloride combined with Dex in general anesthesia for patients with increased serum DBIL and ALP caused by jaundice can maintain hemodynamic stabili-ty,and reduce the dosage of propofol and remifentanil.