论文部分内容阅读
目的 :观察加味参芪地黄汤对系膜增殖性肾小球肾炎兔模型的保护作用并初步探讨了其作用机制。方法 :采用灌胃法给予实验兔加味参芪地黄汤 ,分别观察实验期间模型兔 2 4h尿蛋白定量、肾功能 (BUN、Scr)、血清T细胞数、B细胞数、淋转率、红细胞免疫功能 (C3b -RR、IC -RR)以及肾组织形态学改变。结果 :与模型组相比 ,加味参芪地黄汤具有明显的降尿蛋白、增加T细胞数及淋转率、增强红细胞免疫功能的作用 ,其肾脏病理损害较轻 ,而模型组病理损害较重。结论 :加味参芪地黄汤能够从多方面改善MesPGN兔的肾脏病变
Objective: To observe the protective effect of Jiawei Shenqi Dihuang Decoction on rabbit models of mesangial proliferative glomerulonephritis and to explore its mechanism. Methods: The experimental rabbits were treated with intragastric administration of Modified Shenqi Dihuang Decoction. The urinary protein level, renal function (BUN, Scr), number of serum T cells, number of B cells, turnover rate, and red blood cell immunity were observed during 24 hours in model rabbits. Functional (C3b-RR, IC-RR) and renal morphological changes. Results:Compared with the model group, Modified Shenqi Dihuang Decoction had obvious effects of decreasing urinary protein, increasing the number of T cells and turning rate, and enhancing the immune function of red blood cells. The damage of renal pathology was lighter, and the pathological damage of the model group was heavier. . Conclusion : Modified Shenqi Dihuang Decoction can improve the renal pathological changes of MesPGN rabbits in many aspects