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目的探讨极低出生体重儿生后1周内血胃泌素(GAS)和胃动素(MOT)水平的动态变化。方法用放射免疫法分别测定20例极低出生体重儿(体重<1500 g)、20例低出生体重儿(体重1500～2500 g)生后12 h、24 h、72 h和7天的血GAS、MOT水平,将15例健康足月儿(体重>2500 g)作对照组。结果 (1)极低出生体重儿组生后12 h、24 h、72 h和7天GAS、MOT水平均明显低于对照组(P<0.01);MOT水平低于低出生体重儿组(P<0.01或P<0.05),GAS水平与低出生体重儿组比较差异无统计学意义(P>0.05)。(2)各组生后72 h内血GAS、MOT水平变化不明显,对照组和低出生体重儿组7天时明显高于72 h(P<0.01),极低出生体重儿组MOT 7天时高于72 h(P<0.05),GAS水平变化差异无统计学意义(P>0.05)。(3)≤33周组各时间点GAS、MOT水平均低于≥37周组(P<0.01)。结论 GAS、MOT水平与新生儿体重、胎龄密切相关。极低出生体重儿生后1周内消化功能低下,GAS、MOT水平先降后升,但变化幅度没有低出生体重儿和足月儿明显,提示功能追赶需要更长时间,临床应选择合适的喂养时机和方式。
Objective To investigate the dynamic changes of blood gastrin (GAS) and motilin (MOT) levels within one week of very low birth weight infants. Methods The blood GAS of 20 very low birth weight children (weighing <1500 g), 20 low birth weight children (weighing 1500-2500 g) at 12 h, 24 h, 72 h and 7 d after birth were measured by radioimmunoassay. , MOT level, 15 healthy term children (weight> 2500 g) as the control group. Results (1) The levels of GAS and MOT at 12 h, 24 h, 72 h and 7 d after birth in the very low birth weight children group were significantly lower than those in the control group (P <0.01); the levels of MOT were lower than those in the low birth weight group <0.01 or P <0.05). There was no significant difference between GAS and low birth weight infants (P> 0.05). (2) The blood levels of GAS and MOT did not change significantly within 72 hours after birth in all groups, and were significantly higher than those in control group and low birth weight infants for 72 days (P <0.01) At 72 h (P <0.05), there was no significant difference in GAS level (P> 0.05). (3) The levels of GAS and MOT in patients with ≤33 weeks group were lower than those in patients ≥37 weeks (P <0.01). Conclusions The levels of GAS and MOT are closely related to birth weight and gestational age. Very low birth weight within 1 week after birth, children with poor digestive function, GAS, MOT levels first and then increased, but the rate of change was not low birth weight children and full-term children, suggesting that catch-up requires longer, clinical should choose the appropriate Feeding timing and method.