【摘 要】
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BACKGROUND AND OBJECTIVEWhile conventional risk factors for stroke are well-established, genetic factors are thought to contribute up to 40% of the risk. This study was designed to estimate the geneti
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BACKGROUND AND OBJECTIVEWhile conventional risk factors for stroke are well-established, genetic factors are thought to contribute up to 40% of the risk. This study was designed to estimate the genetic correlations with the three major subtypes of ischemic stroke.
METHODSData were obtained from the Meta-Stroke study, including 15 individual studies, contributing 12, 389 total ischemic strokes cases. In this study, data obtained included genotype, phenotype and demographic details. Stroke subtype was determined, identi-fying cases with large artery atherosclerosis (LAA), cardioembolism or small vessel (lacunar) disease (SVD). A meta-analysis of allelic effects for LAA and SVD was performed for 2, 167 LAA cases, 1, 854 SVD cases and 51, 976 controls.
RESULTSThe results revealed a high genetic relationship between LAA and SVD using both linear mixed models and profile scores. The meta-analysis of LAA and SVD identified a strong association for single nucleotide polymorphisms near the opioid receptor M-1 (OPRM1) gene.
CONCLUSIONThis study of patients with ischemic stroke found an extensive genetic overlap between large artery atherosclerotic and small vessel ischemic stroke.
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