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神经阻滞剂(NL)引起的锥体外系运动障碍(EPS)有三种主要的类型(急性肌张力不全、静坐不能和类巴金森氏症)。它们通常出现在NL治疗开始的几天或几周内,可以通过调整NL剂量,更换药物或者加用抗巴金森氏症药物(AP)来控制。这些症状的病因可能是药物引起脑内黑质纹状体中的多巴胺-乙酰胆硷的不平衡。这些运动障碍与许多因素如生物敏感性、NL的分子结构、剂量、治疗持续时间、年龄和性别有关。已报告的发病率为20～95%。临床和精神药物学研究提出钙与这些
There are three main types of extrapyramidal motor disorders (EPS) caused by nerve blockers (NL) (acute dystonia, sedentary and Parkinson’s). They usually occur within a few days or weeks of starting NL treatment and can be controlled by adjusting the NL dose, changing medications, or adding anti-Parkinson’s disease (AP) drugs. The etiology of these symptoms may be drug-induced dopamine-acetylcholine imbalance in the nigrostriatal brain. These dyskinesias are associated with many factors such as biological susceptibility, molecular structure of NL, dosage, duration of treatment, age and gender. The reported incidence rate is 20-95%. Clinical and psychopharmacological studies have proposed calcium with these