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2006年6月23日,Molecular Cell 学术期刊刊登了一篇关于研究乙肝病毒的重要进展的文章。文章云,美国斯克利普斯研究院 Mark Yeager 教授和 Francis V.Chisari 教授领导的两个实验室,利用低温电子显微镜技术和计算机图象分析方法,检测了转基因小鼠的乙肝病毒蛋白外壳和从人类患者血样中分离出的病毒颗粒的天然结构,并将两个存在于被感染细胞中的乙肝病毒的两种中间体形式显现出来。同时,通过冷冻样本,研究人员能够利用低温电子显微镜,成像这种病毒颗粒,并首
On June 23, 2006, the Molecular Cell scholar published an article on important advances in the study of hepatitis B virus. Article clouds, the United States Scripps Research Institute Professor Mark Yeager and Professor Francis V.Chisari two laboratories led by the use of low temperature electron microscopy and computer image analysis methods, detection of transgenic mice hepatitis B virus protein shell and from The natural structure of the virus particles isolated from the blood samples of human patients reveals the two intermediate forms of the two hepatitis B viruses present in the infected cells. At the same time, by freezing samples, researchers can visualize the virus particles using cryo-electron microscopy