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目的 :检测卵巢上皮性肿瘤患者血清血管内皮生长因子 (VEGF)的水平变化并探讨其临床意义。方法 :应用双抗体夹心酶联免疫吸附法 (ELISA)分别检测正常健康妇女 (正常组 ,2 5例 ) ,卵巢良性上皮性肿瘤妇女(良性组 ,43例 ) ,交界性上皮性肿瘤妇女 (交界组 ,1 4例 )和恶性上皮性肿瘤妇女 (恶性组 ,39例 )外周血中VEGF的水平。结果 :恶性组VEGF水平明显高于交界组、良性组和正常组 (P <0 .0 1 ) ,交界组VEGF水平明显高于良性组和正常组 (P <0 .0 5) ,良性组与正常组VEGF水平之间无明显差异 (P >0 .0 5)。恶性组临床分期晚 (Ⅲ、Ⅳ期 )的患者VEGF水平明显高于临床分期早的患者 (Ⅰ、Ⅱ期 ,P <0 .0 1 ) ,手术后VEGF水平明显低于手术前 (P <0 .0 1 ) ,并且与术中切除的干净程度有关 (P <0 .0 5) ,交界组手术后VEGF水平也明显低于手术前 (P <0 .0 5) ,而良性组手术前后VEGF水平无明显差异 (P >0 .0 5)。各组VEGF水平分别与肿瘤病理组织学类型、病理分级和患者年龄均无明显关系 (P >0 .0 5)。结论 :VEGF与卵巢上皮性肿瘤的发生发展密切相关 ,可能成为反映卵巢上皮性肿瘤恶性行为的重要标志物。
Objective: To detect the level of serum vascular endothelial growth factor (VEGF) in patients with epithelial ovarian cancer and to explore its clinical significance. Methods: The normal healthy women (normal group, 25 cases), ovarian benign epithelial tumor women (benign group, 43 cases), borderline epithelial tumor women (borderline) were detected by double antibody sandwich enzyme-linked immunosorbent assay Group, 14 cases) and malignant epithelial tumor in women (malignant group, 39 cases) VEGF levels in peripheral blood. Results: The VEGF level in malignant group was significantly higher than that in junctional group, benign group and normal group (P <0.01). The VEGF level in junctional group was significantly higher than that in benign group and normal group (P <0.05) There was no significant difference between normal group and normal group (P> 0.05). The level of VEGF in patients with malignant stage was significantly higher than that in patients with clinical stage (stageⅠ, Ⅱ, P <0.01), and the level of VEGF in the patients with stage Ⅲ and Ⅳ was significantly lower than that before operation (P <0.05) .0 1), and was related to the degree of resection (P <0.05). The VEGF level in the junctional group was significantly lower than that before operation (P <0.05), while the VEGF level in the benign group was significantly higher than that before operation No significant difference (P> 0.05). The levels of VEGF in each group had no significant correlation with tumor histological type, pathological grade and patient’s age (P> 0.05). Conclusion: VEGF is closely related to the occurrence and development of ovarian epithelial neoplasms and may be an important marker of malignant ovarian epithelial tumors.