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目的 :研究低度恶性纤维粘液样肉瘤 ( low- grade fibromyxoid sarcoma,L GFS)的超微结构特点。方法 :对两例 LGFS进行电子显微镜观察 ,并与文献报道比较。结果 :瘤细胞多呈长梭形或不规则形 ,部分细胞表面见丝状假足样突起 ,核膜光滑 ,或核形不规则呈分叶状 ,核染色质呈细块状 ;大部分瘤细胞胞浆内含丰富的扩张的粗面内质网 ,细胞周围见丰富的胶原纤维 ,部分瘤细胞之间可见桥粒样连接 ,胞浆内见肌微丝并见密斑 ,此外尚见胞浆内神经内分泌颗粒、核内假包涵体样结构、胞浆内长棱形的类似结晶体样的结构及被膜清楚的脂质空泡。讨论 :L GFS瘤细胞显示纤维母细胞和肌纤维母细胞的超微结构特征 ,在肿瘤超微病理诊断和鉴别诊断中有重要价值。
Objective: To study the ultrastructural features of low-grade fibromyxoid sarcoma (L-GFS). Methods: Two cases of LGFS were observed by electron microscopy and compared with literature reports. RESULTS: The tumor cells were mostly spindle-shaped or irregularly shaped. Filament-like prosthetic processes were seen on some cell surfaces. The nuclear membrane was smooth, or the nucleus was irregularly lobulated, and the nuclear chromatin was a lump; most of the tumors were The cytoplasm is rich in the expansion of the rough endoplasmic reticulum, seen around the cell rich in collagen fibers, some of the bridge between the tumor cells can see the bridge, the cytoplasm see muscle filaments and dense spots, in addition to the cell Intracytoplasmic neuroendocrine granules, pseudonucleated inclusion-like structures in the cytoplasm, long prism-like crystalline-like structures in the cytoplasm and clear lipid vacuoles in the capsule. Discussion: L GFS tumor cells show ultrastructural features of fibroblasts and myofibroblasts, which are of great value in the pathological diagnosis and differential diagnosis of tumors.