论文部分内容阅读
目的研究严重烧伤患者休克期降钙素基因相关肽(CGRP)、神经肽Y(NPY)的变化对心脏功能的影响。方法将60例严重烧伤(烧伤总面积32％-96％TBSA)患者设为试验组,常规进行休克期液体复苏和创面处理;另选60例健康志愿者作为对照组。检测试验组患者伤后1、3、6、12、24、48 h和对照组人员血液中CGRP、NPY、心肌肌钙蛋白T(cTnT)的含量,并对其进行相关性分析。结果伤后3 h试验组患者CGRP水平为(28±6)ng／L,较对照组(55±7)ng／L降低,12 h达低谷(15±4)ng／L,伤后48 h仍低于对照组(P<0．05)。伤后1h试验组NPY、cTnT值[(136±20) ng／L、(0．41±0．08)μg/L]较对照组[(86±13)g／L、(0.16±0．06)／μg／L]升高,12 h达峰值[(189±31)ng／L、(1．78±0．47)μg／L],48 h仍高于对照组(P<0．05)。CGRP与cTnT变化呈显著负相关(r=-0.76,P<0．01);NPY与cTnT变化呈显著正相关(r=0．79,P<0．01)。结论血液中CGRP值降低、NPY值升高在严重烧伤休克期心肌损害中可能起着重要作用。
Objective To investigate the effects of changes of calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) on cardiac function in patients with severe burns. Methods Sixty patients with severe burn (total burn area 32% -96% TBSA) were enrolled in the study. Fluid resuscitation and wound healing were performed routinely in shock period. Sixty healthy volunteers were selected as the control group. The levels of CGRP, NPY, cardiac troponin T (cTnT) in the blood of the test group were detected at 1, 3, 6, 12, 24, and 48 h after injury and the control group were analyzed. Results The level of CGRP in the experimental group was (28 ± 6) ng / L at 3 h after injury, lower than that of the control group (55 ± 7) ng / L, reaching a low level of (15 ± 4) ng / Still lower than the control group (P <0.05). Compared with the control group, the NPY and cTnT values in the experimental group ([(136 ± 20) ng / L, (0.41 ± 0.08) μg / L] (P <0. 06) / μg / L], peaked at 12 h [(189 ± 31) ng / L and (1.78 ± 0.47) μg / L], respectively. 05). There was a significant negative correlation between CGRP and cTnT (r = -0.76, P <0.01). There was a significant positive correlation between NPY and cTnT (r = 0.79, P <0.01). Conclusion The blood CGRP value decreased, NPY value may play an important role in myocardial damage during severe burn shock.