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目的观察研究盐酸帕洛诺司琼在原发性肝癌肝动脉化疗栓塞(transcatheter arterial chemoembolization,TA-CE)术中的止吐作用。方法 48例原发性肝癌患者随机分为观察组和对照组,观察组应用盐酸帕洛诺司琼0.25mg,术前半小时静脉推注。对照组应用格拉司琼6 mg,术前半小时静脉推注。观察术后第1、3天两组患者恶心、呕吐控制情况及不良反应。结果术后第1天观察组与对照组治疗恶心总有效率分别为95.83%、87.50%,治疗呕吐总有效率分别为100.00%、87.50%,两组比较差异均有统计学意义(均P<0.05)。第3天观察组与对照组治疗恶心总有效率分别为91.67%、54.16%,治疗呕吐总有效率分别为83.33%、50.00%,两组比较差异均有统计学意义(均P<0.05)。不良反应发生率两组均为4.16%,差异无统计学意义(P>0.05)。结论盐酸帕洛诺司琼在原发性肝癌TACE术中的止吐效果好,且持续时间长,尤其对迟发性呕吐的治疗效果较好。
Objective To observe the antiemetic effect of palonosetron hydrochloride in the treatment of primary hepatic carcinoma with transcatheter arterial chemoembolization (TA-CE). Methods 48 patients with primary liver cancer were randomly divided into observation group and control group. Palonosetron hydrochloride 0.25 mg and intravenous bolus injection were given in the observation group for half an hour before operation. The control group, granisetron 6 mg, intravenous injection of a half hour before surgery. The patients in the first and third days after operation were observed for nausea and vomiting control and adverse reactions. Results The total effective rates of the treatment group and the control group on the first day after operation were 95.83% and 87.50%, respectively. The total effective rates of the treatment of vomiting were 100.00% and 87.50%, respectively, with significant difference between the two groups (P < 0.05). On the third day, the total effective rates of the treatment group and the control group were 91.67% and 54.16%, respectively. The total effective rates of the treatment vomiting were 83.33% and 50.00% respectively. There were significant differences between the two groups (all P <0.05). The incidence of adverse reactions in both groups were 4.16%, the difference was not statistically significant (P> 0.05). Conclusion Palonosetron Hydrochloride has an antiemetic effect in TACE of primary hepatocellular carcinoma and has a long duration, especially for the treatment of delayed emesis.