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目的探讨乙型肝炎肝硬化患者血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及极低密度脂蛋白(VLDL-C)的临床意义。方法回顾性分析浙江大学医学院附属第一医院120例乙型肝炎肝硬化患者临床资料,同时选用我院30例健康体检者临床资料为正常对照。结果与正常体检者相比,乙型肝硬化患者血脂水平明显降低(P<0.05),TC、TG、HDL-C、LDL-C水平与白蛋白、胆碱酯酶水平正相关(P<0.01),TC、TG、LDL-C水平与凝血酶原时间、MELD分级负相关(P<0.01)。结论乙型肝硬化患者血脂水平明显降低,血脂水平与乙肝肝硬化患者肝功能损害明显相关。
Objective To investigate the changes of serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and very low density lipoprotein (VLDL- C) clinical significance. Methods The clinical data of 120 patients with hepatitis B cirrhosis from the First Affiliated Hospital of Medical College of Zhejiang University were retrospectively analyzed. The clinical data of 30 healthy people in our hospital were selected as the normal control. Results The levels of serum lipids in patients with B cirrhosis were significantly lower than those in normal controls (P <0.05). The levels of TC, TG, HDL-C and LDL-C were positively correlated with albumin and cholinesterase levels ), TC, TG, LDL-C levels were negatively correlated with prothrombin time and MELD grade (P <0.01). Conclusion The level of serum lipids in patients with cirrhosis of the liver is significantly lower, and the level of serum lipids is significantly correlated with the liver dysfunction in patients with hepatitis B cirrhosis.