目的探讨纳洛酮及多巴胺对新生儿缺氧缺血性脑病(HIE)的保护作用及意义。方法将62例重度HIE随机分为两组,常规治疗组38例,观察组28例,在常规治疗的基础上使用纳洛酮和多巴胺治疗,观察和比较两组的疗效。结果观察组总有效率89.2%,对照组总有效率61.8%,两组总有效率经卡方检验,有显著性差异(χ2=6.69,P<0.05)。结论对重度HIE在对症支持治疗基础上尽早使用纳洛酮及多巴胺,能增加脑血流灌注量,减轻脑水肿,显著减轻缺氧缺血脑损伤程度。 Objective To investigate the protective effect of naloxone and dopamine on neonatal hypoxic-ischemic encephalopathy (HIE) and its significance. Methods Sixty-two patients with severe HIE were randomly divided into two groups: conventional treatment group (n = 38) and observation group (n = 28). Naloxone and dopamine treatment were given on the basis of routine treatment. The curative effect of the two groups were observed and compared. Results The total effective rate was 89.2% in the observation group and 61.8% in the control group. The total effective rate in the two groups was significantly different (χ2 = 6.69, P <0.05) by chi-square test. Conclusions The use of naloxone and dopamine as early as possible on the basis of symptomatic and supportive treatment of severe HIE can increase cerebral blood flow, reduce cerebral edema and significantly reduce the extent of hypoxic-ischemic brain damage.