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Toll样受体(Toll-like Receptors,TLRs)识别病原微生物的保守配基以激活机体的免疫应答是诱导抗感染免疫的关键,但是这样的反应需要在机体精细地调控。TLRs信号及其负调控分子的研究是当前免疫学研究的热点。RP105蛋白最早发现是B细胞所特有的TLR同源体,活化后可诱导B细胞增殖。与其它TRs不同,其分子胞内段缺乏可磷酸化的保守酪氨酸位点。但RP105分子在抗原递呈细胞上(antigen presenting cell,APC)的表达及其功能目前并不十分清楚。
Toll-like Receptors (TLRs) Recognizing the conserved ligands of pathogenic microorganisms to activate the body’s immune response is the key to inducing anti-infective immunity, but such reactions need to be finely regulated in the body. The research of TLRs signal and its negative regulatory molecules is a hot spot in current immunology research. The first discovery of the RP105 protein is a B cell-specific TLR homologue that, upon activation, induces B cell proliferation. Unlike other TRs, its intracellular intracellular domain lacks a phosphorylatable conserved tyrosine site. However, the expression and function of RP105 in antigen presenting cell (APC) is not very clear at present.